Ontology highlight
ABSTRACT:
SUBMITTER: Cai CL
PROVIDER: S-EPMC5578462 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Cai Chen-Leng CL Liang Xingqun X Shi Yunqing Y Chu Po-Hsien PH Pfaff Samuel L SL Chen Ju J Evans Sylvia S
Developmental cell 20031201 6
Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1-expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors that give rise to the cardiac segments missing in isl1 mutants. Isl1 function is required for these progenitors to contribute to the heart. In isl1 mutants, isl1-expressing progenito ...[more]