Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages.

ABSTRACT: The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Until now there has been little evidence for native cardiac precursor cells in the postnatal heart. Herein, we report the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium. A cardiac mesenchymal feeder layer allows renewal of the isolated progenitor cells with maintenance of their capability to adopt a fully differentiated cardiomyocyte phenotype. Tamoxifen-inducible Cre/lox technology enables selective marking of this progenitor cell population including its progeny, at a defined time, and purification to relative h

SUBMITTER: Laugwitz KL 

PROVIDER: S-EPMC5578466 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature