Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development.

ABSTRACT: The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most recently, chronic inflammation has been described as an important factor for the development and progression of MPNs in the biological continuum from early cancer stage to the advanced myelofibrosis stage, the MPNs being described as "A Human Inflammation Model for Cancer Development". This novel concept has been built upon clinical, experimental, genomic, immunological and not least epidemiological studies. Only a few studies have described the development of MPNs by mathematical models, and none have addressed the role of inflammation for clonal evolution and disease progression. Herein, we aim at using mathematical mode

SUBMITTER: Andersen M 

PROVIDER: S-EPMC5578482 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature