Acacetin enhances the therapeutic efficacy of doxorubicin in non-small-cell lung carcinoma cells.

ABSTRACT:

Background

Anthracyclines are efficient and potent agents to treat broad range of cancers but cytotoxicity induced by them limits their use in therapeutics. Use of plant-derived agents help to prevent or delay the process of cancer progression and their combination increases the anti-cancer potential of mainstream compound. However, multidrug resistance is major cause of treatment failure in cancer patients.

Purpose

In this study, combination treatments of fisetin or acacetin with doxorubicin were explored for their potential synergistic effect on non-small-cell lung carcinoma (NSCLC) cells.

Study design

During this study, NSCLC model cell lines A549 and H1299 were used to determine the combinatorial effect of phytochemicals namly acacetin and fisetin with doxorubicin

SUBMITTER: Punia R 

PROVIDER: S-EPMC5578506 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature