Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice.

ABSTRACT: The transcription factors Bcl6 and Blimp1 have opposing roles in the development of the follicular helper T (T_FH ) cells: Bcl6 promotes and Blimp1 inhibits T_FH -cell differentiation. Similarly, Bcl6 activates, while Blimp1 represses, expression of the T_FH -cell marker PD-1. However, Bcl6 and Blimp1 repress each other's expression, complicating the interpretation of the regulatory network. Here we sought to clarify the extent to which Bcl6 and Blimp1 independently control T_FH -cell differentiation by generating mice with T-cell specific deletion of both Bcl6 and Blimp1 (double conditional KO [dcKO] mice). Our data indicate that Blimp1 does not control T_FH -cell differentiation independently of Bcl6. However, a population of T follicular

SUBMITTER: Xie MM 

PROVIDER: S-EPMC5578616 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature