Semi-quantitative MALDI-TOF for antimicrobial susceptibility testing in Staphylococcus aureus.

ABSTRACT: Antibiotic resistant bacterial infections are a significant problem in the healthcare setting, in many cases requiring the rapid administration of appropriate and effective antibiotic therapy. Diagnostic assays capable of quickly and accurately determining the pathogen resistance profile are therefore crucial to initiate or modify care. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) is a standard method for species identification in many clinical microbiology laboratories and is well positioned to be applied towards antimicrobial susceptibility testing. One recently reported approach utilizes semi-quantitative MALDI-TOF MS for growth rate analysis to provide a resistance profile independent of resistance mechanism. This method was previously s

SUBMITTER: Maxson T 

PROVIDER: S-EPMC5578647 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature