Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb.

ABSTRACT: Epigenomic mapping of enhancer-associated chromatin modifications facilitates the genome-wide discovery of tissue-specific enhancers in vivo. However, reliance on single chromatin marks leads to high rates of false-positive predictions. More sophisticated, integrative methods have been described, but commonly suffer from limited accessibility to the resulting predictions and reduced biological interpretability. Here we present the Limb-Enhancer Genie (LEG), a collection of highly accurate, genome-wide predictions of enhancers in the developing limb, available through a user-friendly online interface. We predict limb enhancers using a combination of >50 published limb-specific datasets and clusters of evolutionarily conserved transcription factor binding sites, taking advantage of the patte

SUBMITTER: Monti R 

PROVIDER: S-EPMC5578682 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature