Preclinical Alterations in Myocardial Microstructure in People with Metabolic Syndrome.

ABSTRACT:

Objective

Metabolic syndrome (MetS) can lead to myocardial fibrosis, diastolic dysfunction, and eventual heart failure. This study evaluated alterations in myocardial microstructure in people with MetS by using a novel algorithm to characterize ultrasonic signal intensity variation.

Methods

Among 254 participants without existing cardiovascular disease (mean age 42 ± 11 years, 75% women), there were 162 with MetS, 47 with obesity without MetS, and 45 nonobese controls. Standard echocardiography was performed, and a novel validated computational algorithm was used to investigate myocardial microstructure based on sonographic signal intensity and distribution. The signal intensity coefficient (SIC [left ventricular microstructure]) was examined.

Results

The SIC was sign

SUBMITTER: Ho JE 

PROVIDER: S-EPMC5578717 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature