Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection.

ABSTRACT:

Objective

Chronic HIV-1 infection leads to widespread inflammation and immune dysregulation. The gastrointestinal mucosa, a primary site for HIV-1 replication, is thought to play a significant role in this response. MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression, including immune activation and inflammation. Here we investigate miR expression and function in the colonic mucosa during HIV-1 infection.

Design and methods

Using miR profiling, we examined miR expression in the colonic mucosa of HIV-infected patients. These miRs were further parsed to identify those that most likely function in HIV-related inflammation. Using bioinformatics tools, we identified potential target genes which were confirmed using in-vitro functional testing.

Results

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SUBMITTER: Fulcher JA 

PROVIDER: S-EPMC5578872 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature