Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC5578875 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Nature methods 20170807 9
Top-down proteomics, the analysis of intact proteins in their endogenous form, preserves valuable information about post-translation modifications, isoforms and proteolytic processing. The quality of top-down liquid chromatography-tandem MS (LC-MS/MS) data sets is rapidly increasing on account of advances in instrumentation and sample-processing protocols. However, top-down mass spectra are substantially more complex than conventional bottom-up data. New algorithms and software tools for confide ...[more]