Combination Antipsychotic Therapies: An Analysis From a Longitudinal Pragmatic Trial.

ABSTRACT:

Background

Combination antipsychotics (CAs) are prescribed in schizophrenia despite limited evidence of efficacy. To explore the effect of switching from CA to monotherapy, we performed an exploratory analysis of the PROACTIVE (Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared with Injectables: Evaluating Efficacy) study data, in which 305 patients with schizophrenia and schizoaffective disorder were followed for 30 months after randomization to long-acting injectable (LAI) risperidone or second-generation oral antipsychotic (OA).

Methods

Patients who entered the PROACTIVE study on CA (n = 50), LAI (n = 20), or OA (n = 206) were compared in terms of time to relapse and clinical measures.

Findings

The OA group had significantly fewer hospitalizations th

SUBMITTER: Foster A 

PROVIDER: S-EPMC5578887 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature