The effect of oral preexposure prophylaxis on the progression of HIV-1 seroconversion.

ABSTRACT:

Objective

To investigate whether oral preexposure prophylaxis (PrEP) alters timing and patterns of seroconversion when PrEP use continues after HIV-1 infection.

Design

Retrospective testing of the timing of Fiebig stage HIV-1 seroconversion in the Partners PrEP Study, a randomized placebo-controlled clinical trial of PrEP conducted in Kenya and Uganda.

Methods

Specimens from 138 seroconverters were collected every 3 months and when HIV-1 infection was suspected based on monthly rapid HIV-1 tests. Progression of seroconversion was compared between randomized groups (PrEP versus placebo) and per-protocol groups (placebo versus PrEP participants with detectable tenofovir during the seroconversion period) using laboratory assessment of Fiebig stage. Delay in site-detectio

SUBMITTER: Donnell D 

PROVIDER: S-EPMC5578893 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature