Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: A birth cohort study.

ABSTRACT:

Background

Filaggrin gene (FLG) expression, particularly in the skin, has been linked to the development of the skin barrier and is associated with eczema risk. However, knowledge as to whether FLG expression in umbilical cord blood (UCB) is associated with eczema development and prediction is lacking.

Objective

This study sought to assess whether FLG expression in UCB associates with and predicts the development of eczema in infancy.

Methods

Infants enrolled in a birth cohort study (n=94) were assessed for eczema at ages 3, 6, and 12 months. Five probes measuring FLG transcripts expression in UCB were available from genomewide gene expression profiling. FLG genetic variants R501X, 2282del4, and S3247X were genotyped. Associations were assessed using Poisson regressio

SUBMITTER: Ziyab AH 

PROVIDER: S-EPMC5578904 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature