The Duffy antigen receptor for chemokines regulates asthma pathophysiology.

ABSTRACT:

Background

The Duffy antigen receptor for chemokines (DARC) is an atypical receptor that regulates pro-inflammatory cytokines. However, the role of DARC in asthma pathophysiology is unknown.

Objective

To determine the role of DARC in allergic airways disease in mice, and the association between DARC single nucleotide polymorphisms (SNPs) and clinical outcomes in patients with asthma.

Methods

Mice with targeted disruption of the Darc gene (Darc^∆E2 ) or WT mice were challenged over 3 weeks with house dust mite (HDM) antigen. Allergic airways disease was assessed 24 hours and 7 days following the final challenge. Additionally, associations between DARC SNPs and clinical outcomes were analysed in a cohort of poorly controlled asthmatics.

Results

Total ai

SUBMITTER: Chapman DG 

PROVIDER: S-EPMC5578916 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature