Protective ventilation reduces Pseudomonas aeruginosa growth in lung tissue in a porcine pneumonia model.

ABSTRACT:

Background

Mechanical ventilation with positive end expiratory pressure and low tidal volume, i.e. protective ventilation, is recommended in patients with acute respiratory distress syndrome. However, the effect of protective ventilation on bacterial growth during early pneumonia in non-injured lungs is not extensively studied. The main objectives were to compare two different ventilator settings on Pseudomonas aeruginosa growth in lung tissue and the development of lung injury.

Methods

A porcine model of severe pneumonia was used. The protective group (n = 10) had an end expiratory pressure of 10 cm H₂O and a tidal volume of 6 ml x kg^-1. The control group (n = 10) had an end expiratory pressure of 5 cm H₂O and a tidal volume of 10 ml x kg

SUBMITTER: Sperber J 

PROVIDER: S-EPMC5578946 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature