Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety.

ABSTRACT: Generalized anxiety and major depression have become increasingly common in the United States, affecting 18.6 percent of the adult population. Mood disorders can be debilitating, and are often correlated with poor general health, life dissatisfaction, and the need for disability benefits due to inability to work. Recent evidence suggests that some mood disorders have a circadian component, and disruptions in circadian rhythms may even trigger the development of these disorders. However, the molecular mechanisms of this interaction are not well understood. Polymorphisms in a circadian clock-related gene, PER3, are associated with behavioral phenotypes (extreme diurnal preference in arousal and activity) and sleep/mood disorders, including seasonal affective disorder (SAD). Here we show that

SUBMITTER: Liberman AR 

PROVIDER: S-EPMC5579000 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature