MiR-96 attenuates status epilepticus-induced brain injury by directly targeting Atg7 and Atg16L1.

ABSTRACT: Status epilepticus (SE) can cause brain damage and lead to neural dysfunction. Developing novel targets for SE therapy and diagnosis is important and necessary. Previously, we found several differentially expressed microRNAs (miRNAs) in the developing hippocampus following SE, including the autophagy-related miR-96. In the present study, we employed immunofluorescence staining and Western blot analysis to assess the expression of autophagy-related 7 (Atg7) and Atg16L1 and the status of autophagosome formation in the hippocampus of immature rats with SE. Additional in vivo intervention was also performed to investigate the potential therapeutic function of miR-96 in developing rats with SE. We found that Atg7 and Atg16L1 were up-regulated in the neurons after SE, together with an increase i

SUBMITTER: Gan J 

PROVIDER: S-EPMC5579030 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature