Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study.

ABSTRACT:

Purpose

Data on the relation between linoleic acid (LA) and alpha-linolenic acid (ALA) and type 2 diabetes mellitus (T2DM) risk are scarce and inconsistent. The aim of this study was to investigate the association of serum LA and ALA with fasting and 2 h post-load plasma glucose and glycated hemoglobin (HbA1c).

Method

This study included 667 participants from third examination (2000) of the population-based Hoorn study in which individuals with glucose intolerance were overrepresented. Fatty acid profiles in serum total lipids were measured at baseline, in 2000. Diabetes risk markers were measured at baseline and follow-up in 2008. Linear regression models were used in cross-sectional and prospective analyses.

Results

In cross-sectional analyses (n = 667), serum LA wa

SUBMITTER: Cabout M 

PROVIDER: S-EPMC5579177 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature