A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer.

ABSTRACT: As lung cancer has increased to the most common cause of cancer death worldwide, prognostic biomarkers and effective targeted treatments remain lacking despite advances based on patients' stratification. Multiple core cyclins, best known as drivers of cell proliferation, are commonly deregulated in lung cancer where they may serve as oncogenes. The recent expansion of the cyclin family raises the question whether new members might play oncogenic roles as well. Here, we investigated the protein levels of eight atypical cyclins in lung cancer cell lines and formalin-fixed and paraffin-embedded (FFPE) human tumors, as well as their functional role in lung cancer cells. Of the new cyclins evaluated, CNTD2 was significantly overexpressed in lung cancer compared to adjacent normal tissue, and ex

SUBMITTER: Gasa L 

PROVIDER: S-EPMC5579190 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature