Transferrin-navigation Nano Artificial Antibody Fluorescence Recognition of Circulating Tumor Cells.

ABSTRACT: Specific recognition of circulating tumor cells (CTCs) is of great significance for cancer diagnosis and personalized therapy. The antibodies and aptamer are commonly used for recognition of CTCs, but they often suffer from low stability and high cost. Therefore, chemically stable and low-cost artificial recognition elements are still highly demanded. Herein, we prepared nano artificial antibody based on molecular imprinting and applied for fluorescence recognition of CTCs. Surface imprinting was employed to construct a transferrin (TRA)-imprinted layer on the surface of rhodamine doped silica nanoparticles. Take advantage of the specific interaction between TRA and TRA receptor (overexpressed on cancer cells), the as-prepared TRA-imprinted artificial antibody was allowed for specific targ

SUBMITTER: Zhang W 

PROVIDER: S-EPMC5579199 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature