Stability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4.

ABSTRACT: In the last decades, a plethora of in vitro studies with living human cells contributed a vast amount of knowledge about cellular and molecular effects of microgravity. Previous studies focused mostly on the identification of gravity-responsive genes, whereas a multi-platform analysis at an integrative level, which specifically evaluates the extent and robustness of transcriptional response to an altered gravity environment was not performed so far. Therefore, we investigated the stability of gene expression response in non-activated human Jurkat T lymphocytic cells in different gravity environments through the combination of parabolic flights with a suborbital ballistic rocket and 2D clinostat and centrifuge experiments, using strict controls for excluding all possible other factors of in

SUBMITTER: Thiel CS 

PROVIDER: S-EPMC5579209 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature