A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors.

ABSTRACT: Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of coxibs for association with CAD. Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narrow potential mechanisms affecting CAD risk as we hypothesized that the affected genes may also display genomic signals of coronary disease risk. A Drug Gene Interaction Database search identified 47 gene products to be affected by coxibs. We traced association signals in 200-kb regions surrounding these genes in 84,813 CAD cases and 202,543 controls. Based on a threshold of 1 × 10^-5 (Bonferroni correction for 3131 haplotype blocks),

SUBMITTER: Brænne I 

PROVIDER: S-EPMC5579257 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature