CXCL12 overexpression promotes the angiogenesis potential of periodontal ligament stem cells.

ABSTRACT: Periodontal ligament stem cells (PDLSCs) are a major source of mesenchymal stem cells (MSCs) in adults and are effective for tissue engineering, like promoting angiogenesis and bone regeneration. CXCL12 has been reported to be involved in the recruitment and engraftment of MSCs in wound sites. However, whether CXCL12 potentiates the angiogenesis of PDLSCs is not clear. In this experiment, we transduced PDLSCs with CXCL12, and evaluated the angiogenesis potential of CXCL12-modified PDLSCs through in vitro and in vivo studies. The results showed that CXCL12 overexpression significantly stimulated the gene and protein expressions of bFGF, VEGF, SCF and PLGF in PDLSCs; CXCL12 gene modified PDLSCs formed longer capillary-like structure; Moreover, in vivo transplanted PDLSCs transduced with CXCL

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5579269 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature