FMISO-PET-derived brain oxygen tension maps: application to glioblastoma and less aggressive gliomas.

ABSTRACT: Quantitative imaging modalities for the analysis of hypoxia in brain tumors are lacking. The objective of this study was to generate absolute maps of tissue p_tO₂ from [¹⁸F]-FMISO images in glioblastoma and less aggressive glioma patients in order to quantitatively assess tumor hypoxia. An ancillary objective was to compare estimated p_tO₂ values to other biomarkers: perfusion weighted imaging (PWI) and tumor metabolism obtained from ¹H-MR mono-voxel spectroscopy (MRS). Ten patients with glioblastoma (GBM) and three patients with less aggressive glioma (nGBM) were enrolled. All patients had [¹⁸F]-FMISO and multiparametric MRI (anatomic, PWI, MRS) scans. A non-linear regression was performed to generate p_t

SUBMITTER: Chakhoyan A 

PROVIDER: S-EPMC5579277 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature