SK4 channels modulate Ca²⁺ signalling and cell cycle progression in murine breast cancer.

ABSTRACT: Oncogenic signalling via Ca²⁺ -activated K⁺ channels of intermediate conductance (SK4, also known as K_Ca 3.1 or IK) has been implicated in different cancer entities including breast cancer. Yet, the role of endogenous SK4 channels for tumorigenesis is unclear. Herein, we generated SK4-negative tumours by crossing SK4-deficient (SK4 KO) mice to the polyoma middle T-antigen (PyMT) and epidermal growth factor receptor 2 (cNeu) breast cancer models in which oncogene expression is driven by the retroviral promoter MMTV. Survival parameters and tumour progression were studied in cancer-prone SK4 KO in comparison with wild-type (WT) mice and in a syngeneic orthotopic mouse model following transplantation of SK4-negative or WT tumour cells. SK4 activity was modulat

SUBMITTER: Steudel FA 

PROVIDER: S-EPMC5579333 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature