The Shigella type III effector IpgD recodes Ca²⁺ signals during invasion of epithelial cells.

ABSTRACT: The role of second messengers in the diversion of cellular processes by pathogens remains poorly studied despite their importance. Among these, Ca²⁺ virtually regulates all known cell processes, including cytoskeletal reorganization, inflammation, or cell death pathways. Under physiological conditions, cytosolic Ca²⁺ increases are transient and oscillatory, defining the so-called Ca²⁺ code that links cell responses to specific Ca²⁺ oscillatory patterns. During cell invasion, Shigella induces atypical local and global Ca²⁺ signals. Here, we show that by hydrolyzing phosphatidylinositol-(4,5)bisphosphate, the Shigella type III effector IpgD dampens inositol-(1,4,5)trisphosphate (InsP₃) levels. By modifying InsP

SUBMITTER: Sun CH 

PROVIDER: S-EPMC5579377 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature