TrkA is a binding partner of NPM-ALK that promotes the survival of ALK⁺ T-cell lymphoma.

ABSTRACT: Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK⁺ ) T-cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM-ALK⁺ T-cell lymphoma is not completely understood. Wild-type ALK is a receptor tyrosine kinase that is physiologically expressed in neural tissues during early stages of human development, which suggests that ALK may interact with neurotrophic factors. The aberrant expression of NPM-ALK results from a translocation between the ALK gene on chromosome 2p23 and the NPM gene on chromosome 5q35. The nerve growth factor (NGF) is the first neurotrophic factor attributed to non-neural functions including cancer cell survival, proliferation, and metastasis. These functions are primarily mediat

SUBMITTER: Shi W 

PROVIDER: S-EPMC5579389 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature