Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements.

ABSTRACT: Nutrient needs, including those of the essential nutrient choline, are a population wide distribution. Adequate Intake (AI) recommendations for dietary choline (put forth by the National Academies of Medicine to aid individuals and groups in dietary assessment and planning) are grouped to account for the recognized unique needs associated with age, biological sex, and reproductive status (i.e., pregnancy or lactation). Established and emerging evidence supports the notion that common genetic variants are additional factors that substantially influence nutrient requirements. This review summarizes the genetic factors that influence choline requirements and metabolism in conditions of nutrient deprivation, as well as conditions of nutrient adequacy, across biological sexes and reproductive s

SUBMITTER: Ganz AB 

PROVIDER: S-EPMC5579630 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature