Systematic Review of the Relation Between Intestinal Microbiota and Toll-Like Receptors in the Metabolic Syndrome: What Do We Know So Far?

ABSTRACT:

Introduction

Metabolic syndrome is an emerging problem in developed countries and presents itself as a potential threat worldwide. The role of diabetes, dyslipidaemia and hepatic steatosis as pivotal components of the metabolic syndrome is well known. However, their common persistent chronic inflammation and its potential cause still elude. This systematic review aims to present evidence of the mechanisms that link the intestinal microbioma, innate immunity and metabolic syndrome.

Methods

A comprehensive research was made using PubMed database and 35 articles were selected.

Results

We found that metabolic syndrome is associated to increased levels of innate immunity receptors, namely, Toll-like receptors, both in intestine and systemically and its polymorphisms may ch

SUBMITTER: Portela-Cidade JP 

PROVIDER: S-EPMC5580162 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature