Genetics of depressive symptoms in adolescence.

ABSTRACT:

Background

Despite many attempts to understand the genetic architecture of depression, little progress has been made. The majority of these studies, however, have been carried out in adults and do not account for the potential influence of development.

Methods

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal pregnancy cohort which recruited participants between April 1991 and December 1992. Analyses were replicated in two independent European cohorts. Genome-wide complex trait analysis (GCTA) software was used to investigate SNP-heritability (h²_SNP) of depression across adolescence, the role of puberty was investigated by stratifying these estimates according to pubertal onset. Genome-wide association studies were performed

SUBMITTER: Sallis H 

PROVIDER: S-EPMC5580280 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature