Identifying research priorities for effective retention strategies in clinical trials.

ABSTRACT:

Background

The failure to retain patients or collect primary-outcome data is a common challenge for trials and reduces the statistical power and potentially introduces bias into the analysis. Identifying strategies to minimise missing data was the second highest methodological research priority in a Delphi survey of the Directors of UK Clinical Trial Units (CTUs) and is important to minimise waste in research. Our aim was to assess the current retention practices within the UK and priorities for future research to evaluate the effectiveness of strategies to reduce attrition.

Methods

Seventy-five chief investigators of NIHR Health Technology Assessment (HTA)-funded trials starting between 2009 and 2012 were surveyed to elicit their awareness about causes of missing data withi

SUBMITTER: Kearney A 

PROVIDER: S-EPMC5580283 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature