Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine.

ABSTRACT: A highly integrated approach to the development of a process for the continuous synthesis and purification of diphenhydramine is reported. Mass spectrometry (MS) is utilized throughout the system for on-line reaction monitoring, off-line yield quantitation, and as a reaction screening module that exploits reaction acceleration in charged microdroplets for high throughput route screening. This effort has enabled the discovery and optimization of multiple routes to diphenhydramine in glass microreactors using MS as a process analytical tool (PAT). The ability to rapidly screen conditions in charged microdroplets was used to guide optimization of the process in a microfluidic reactor. A quantitative MS method was developed and used to measure the reaction kinetics. Integration of the continuo

SUBMITTER: Loren BP 

PROVIDER: S-EPMC5580336 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature