Experimental Atom-by-Atom Dissection of Amide-Amide and Amide-Hydrocarbon Interactions in H₂O.

ABSTRACT: Quantitative information about amide interactions in water is needed to understand their contributions to protein folding and amide effects on aqueous processes and to compare with computer simulations. Here we quantify interactions of urea, alkylated ureas, and other amides by osmometry and amide-aromatic hydrocarbon interactions by solubility. Analysis of these data yields strengths of interaction of ureas and naphthalene with amide sp²O, amide sp²N, aliphatic sp³C, and amide and aromatic sp²C unified atoms in water. Interactions of amide sp²O with urea and naphthalene are favorable, while amide sp²O-alkylurea interactions are unfavorable, becoming more unfavorable with increasing alkylation. Hence, amide sp²O-a

SUBMITTER: Cheng X 

PROVIDER: S-EPMC5580340 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature