Immunosuppressive myeloid-derived suppressor cells are increased in splenocytes from cancer patients.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells that are increased in the peripheral blood of cancer patients and limit productive immune responses against tumors. Immunosuppressive MDSCs are well characterized in murine splenic tissue and are found at higher frequencies in spleens of tumor-bearing mice. However, no studies have yet analyzed these cells in parallel human spleens. We hypothesized that MDSCs would be increased in the spleens of human cancer patients, similar to tumor-bearing mice. We compared the frequency and function of MDSC subsets in dissociated human spleen from 16 patients with benign pancreatic cysts and 26 patients with a variety of cancers. We found that total MDSCs (Lin^neg CD11b^pos CD33^pos HL

SUBMITTER: Jordan KR 

PROVIDER: S-EPMC5580403 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature