A scoring system for the evaluation of the mutated <i>Crb1/rd8</i>-derived retinal lesions in C57BL/6N mice.

ABSTRACT: As part of the International Mouse Phenotyping Consortium (IMPC) programme, the MRC Harwell is conducting a large eye morphology phenotyping screen on genetically modified mice compared to the baseline phenotype observed in the background strain of C57BL/6NTac. The C57BL/6NTac strain is known to carry a spontaneous mutation in the Crb1 gene that causes retinal degeneration characterized by the presence of white spots (flecks) in the fundus. These flecks potentially represent a confounding factor, masking similar retinal phenotype abnormalities that may be detected in mutants. Therefore we investigated the frequency, position and extent of the flecks in a large population of C57BL/6NTac mice to provide the basis for evaluating the presence of flecks in mutant mice with the same genet

SUBMITTER: Concas D 

PROVIDER: S-EPMC5580417 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature