Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding.

ABSTRACT:

Background

MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptosis and may serve as prognostic and predictive markers. In this study we aimed to evaluate the role of miRNA-148a and miRNA-625-3p in metastatic colorectal cancer.

Methods

Fifty-four patients with a first-time diagnosed CRC receiving FOLFOX ± Bevacizumab were involved in the study. Tumor samples underwent routine pathology examination including evaluation for tumor budding and KRAS. MiRNA-148a and miRNA-625-3p expression analysis was done by RT-PCR. Associations between expression of both miRNAs and clinico-pathological factors, treatment outcomes and survival

SUBMITTER: Baltruskeviciene E 

PROVIDER: S-EPMC5580437 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature