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Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis.

ABSTRACT: Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new treatments are urgently needed. Developing new virus control modalities requires better understanding of virus-host interactions. Here, we describe how IAV infection triggers cellular apoptosis and how this process can be exploited towards the development of new therapeutics, which might be more effective than the currently available anti-influenza drugs.

SUBMITTER: Shim JM 

PROVIDER: S-EPMC5580480 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis.

Shim Jung Min JM   Kim Jinhee J   Tenson Tanel T   Min Ji-Young JY   Kainov Denis E DE  

Viruses 20170812 8

Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new treatments are urgently needed. Developing new virus control modalities requires better understanding of virus-host interactions. Here, we describe how IAV infection triggers cellular apoptosis and how this process can be exploited towards the development of new therapeutics, which m  ...[more]

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