Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.

ABSTRACT: Blood vessels in the mammalian skeletal system control bone formation and support haematopoiesis by generating local niche environments. While a specialized capillary subtype, termed type H, has been recently shown to couple angiogenesis and osteogenesis in adolescent, adult and ageing mice, little is known about the formation of specific endothelial cell populations during early developmental endochondral bone formation. Here, we report that embryonic and early postnatal long bone contains a specialized endothelial cell subtype, termed type E, which strongly supports osteoblast lineage cells and later gives rise to other endothelial cell subpopulations. The differentiation and functional properties of bone endothelial cells require cell-matrix signalling interactions. Loss of endothelial

SUBMITTER: Langen UH 

PROVIDER: S-EPMC5580829 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature