Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke.

ABSTRACT:

Objective

To examine the association between serum matrix metalloproteinases-9 (MMP-9) levels and prognosis of acute ischemic stroke.

Methods

We measured serum MMP-9 levels in 3,186 participants (2,008 men and 1,178 women) from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). Study outcome data on death, major disability (modified Rankin Scale score ≥3), and vascular disease were collected at 3 months after stroke onset.

Results

During 3 months of follow-up, 767 participants (24.6%) experienced major disability or died. Serum MMP-9 was significantly associated with an increased risk of death and major disability after adjustment for age, sex, time from onset to randomization, current smoking, alcohol drinking, admission NIH Stroke Scale score, diasto

SUBMITTER: Zhong C 

PROVIDER: S-EPMC5580861 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature