In vivo retention of ¹⁸F-AV-1451 in corticobasal syndrome.

ABSTRACT:

Objective

To study the usefulness of ¹⁸F-AV-1451 PET in patients with corticobasal syndrome (CBS).

Methods

We recruited 8 patients with CBS, 17 controls, 31 patients with Alzheimer disease (AD), and 11 patients with progressive supranuclear palsy (PSP) from the Swedish BioFINDER study. All patients underwent clinical assessment, ¹⁸F-AV-1451 PET, MRI, and quantification of β-amyloid pathology. A subset of participants also underwent ¹⁸F-FDG-PET.

Results

In the 8 patients with CBS, 6 had imaging findings compatible with the corticobasal degeneration pathology and 2 with typical AD pathology. In the 6 patients with CBS without typical AD pathology, there were substantial retentions of ¹⁸F-AV-1451 in the motor cortex, corticospi

SUBMITTER: Smith R 

PROVIDER: S-EPMC5580862 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature