Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: A meta-analysis.

ABSTRACT:

Objective

We evaluated recurrent intracerebral hemorrhage (ICH) risk in ICH survivors, stratified by the presence, distribution, and number of cerebral microbleeds (CMBs) on MRI (i.e., the presumed causal underlying small vessel disease and its severity).

Methods

This was a meta-analysis of prospective cohorts following ICH, with blood-sensitive brain MRI soon after ICH. We estimated annualized recurrent symptomatic ICH rates for each study and compared pooled odds ratios (ORs) of recurrent ICH by CMB presence/absence and presumed etiology based on CMB distribution (strictly lobar CMBs related to probable or possible cerebral amyloid angiopathy [CAA] vs non-CAA) and burden (1, 2-4, 5-10, and >10 CMBs), using random effects models.

Results

We pooled data from 10 studie

SUBMITTER: Charidimou A 

PROVIDER: S-EPMC5580863 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature