Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells.

ABSTRACT:

Introduction

The airway epithelium is a physical and immunological barrier that protects the pulmonary system from inhaled environmental insults. Uric acid has been detected in the respiratory tract and can function as an antioxidant or damage associated molecular pattern. We have demonstrated that human airway epithelial cells are a source of uric acid. Our hypothesis is that uric acid production by airway epithelial cells is induced by environmental stimuli associated with chronic respiratory diseases. We therefore examined how airway epithelial cells regulate uric acid production.

Materials and methods

Allergen and cigarette smoke mouse models were performed using house dust mite (HDM) and cigarette smoke exposure, respectively, with outcome measurements of lung uric acid

SUBMITTER: Huff RD 

PROVIDER: S-EPMC5580912 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature