Toward Good Read-Across Practice (GRAP) guidance.

ABSTRACT: Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key role in complying with legislations such as the European REACH regulation, the lack of consensus regarding the extent and type of evidence necessary to support it often hampers its successful application and acceptance by regulatory authorities. Despite a potentially broad user community, expertise is still concentrated across a handful of organizations and individuals. In order to facilitate the effective use of read-across, this document aims to su

SUBMITTER: Ball N 

PROVIDER: S-EPMC5581000 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature