MiR-199a-3p suppresses proliferation and invasion of prostate cancer cells by targeting Smad1.

ABSTRACT:

Objectives

This study was intended to analyze effects of miR-199a-3p and Smad1 on proliferation, migration and invasion of prostate cancer (PCa) cells.

Results

MiR-199a-3p was significantly decreased in PCa tissues in comparison to that in adjacent normal tissues (P < 0.05). Over-expressed miR-199a-3p markedly suppressed proliferation and invasion of PCa cells (P < 0.05). MiR-199a-3p was negatively correlated with Smad1 expression, and overexpression of Smad1 could antagonize the effects of miR-199a-3p on PCa cells.

Materials and methods

The PCa tissues and their adjacent normal tissues were collected from 54 PCa patients. Expressions of miR-199a-3p and Smad1 mRNA in tissues and cells were evaluated with real-time quantitative polymerase chain reaction (

SUBMITTER: Qu F 

PROVIDER: S-EPMC5581043 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature