Identification of long non-coding RNAs biomarkers associated with progression of endometrial carcinoma and patient outcomes.

ABSTRACT: Endometrial carcinoma is a complex disease characterized by both genetic, epigenetic and environmental factors. Increasing evidence has suggested that long non-coding RNAs (lncRNAs) play important roles in the development and progression of cancers. In this study, we performed a comparison analysis for lncRNA expression between patients with early-stage (stage I/II) and those with advanced-stage (stage III/IV) derived from The Cancer Genome Atlas (TCGA) project and identified 17 differentially expressed lncRNAs using student t-test. Five of the 17 differentially expressed lncRNAs were selected as optimal biomarkers that are significantly associated with progression of UCEC using random forest feature selection procedure. A risk classifier of five lncRNAs was developed to as a molecular sig

SUBMITTER: Sun Y 

PROVIDER: S-EPMC5581054 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature