The development and validation of an easy to use automatic QT-interval algorithm.

ABSTRACT:

Background

To evaluate QT-interval dynamics in patients and in drug safety analysis, beat-to-beat QT-interval measurements are increasingly used. However, interobserver differences, aberrant T-wave morphologies and changes in heart axis might hamper accurate QT-interval measurements.

Objective

To develop and validate a QT-interval algorithm robust to heart axis orientation and T-wave morphology that can be applied on a beat-to-beat basis.

Methods

Additionally to standard ECG leads, the root mean square (ECGRMS), standard deviation and vectorcardiogram were used. QRS-onset was defined from the ECGRMS. T-wave end was defined per individual lead and scalar ECG using an automated tangent method. A median of all T-wave ends was used as the general T-wave end per beat. Supi

SUBMITTER: Hermans BJM 

PROVIDER: S-EPMC5581168 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature