BAP1 regulates IP3R3-mediated Ca²⁺ flux to mitochondria suppressing cell transformation.

ABSTRACT: BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1^+/-) developed one and often several BAP1^-/- malignancies in their lifetime, mostly malignant mesothelioma, uveal melanoma, and so on. Moreover, BAP1-acquired biallelic mutations are frequent in human cancers. BAP1 tumour suppressor activity has been attributed to its nuclear localization, where it helps to maintain genome integrity. The possible activity of BAP1 in the cytoplasm is unknown. Cells with reduced levels of BAP1 exhibit chromosomal abnormalities and decreased DNA repair by homologous recombination, indicating that BAP1 dosage is critical. Cells with extensive DNA

SUBMITTER: Bononi A 

PROVIDER: S-EPMC5581194 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature