Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir.

ABSTRACT: New methods for long-lasting protection against sexually transmitted disease, such as the human immunodeficiency virus (HIV), are needed to help reduce the severity of STD epidemics, especially in developing countries. Intravaginal delivery of therapeutics has emerged as a promising strategy to provide women with local protection, but residence times of such agents are greatly reduced by the protective mucus layer, fluctuating hormone cycle, and complex anatomical structure of the reproductive tract. Polymeric nanoparticles (NPs) capable of encapsulating the desired cargo, penetrating through the mucosal surfaces, and delivering agents to the site of action have been explored. However, prolonged retention of polymer carriers and their enclosed materials may also be needed to ease adherence

SUBMITTER: Mohideen M 

PROVIDER: S-EPMC5581224 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature