SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling.

ABSTRACT:

Rationale

The highly conserved NOTCH (neurogenic locus notch homolog protein) signaling pathway functions as a key cell-cell interaction mechanism controlling cell fate and tissue patterning, whereas its dysregulation is implicated in a variety of developmental disorders and cancers. The pivotal role of endothelial NOTCH in regulation of angiogenesis is widely appreciated; however, little is known about what controls its signal transduction. Our previous study indicated the potential role of post-translational SUMO (small ubiquitin-like modifier) modification (SUMOylation) in vascular disorders.

Objective

The aim of this study was to investigate the role of SUMOylation in endothelial NOTCH signaling and angiogenesis.

Methods and results

Endothelial SENP1 (sentrin-spec

SUBMITTER: Zhu X 

PROVIDER: S-EPMC5581236 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature