Renal cell carcinoma: molecular characterization and evolving treatment paradigms.

ABSTRACT:

Purpose of review

The treatment landscape of advanced renal cell carcinoma (RCC) continues to shift as both new targeted therapies and immunotherapies show efficacy in treating the disease. Contemporary insights into the molecular characterization of RCC are likely to fuel the development of additional therapies. This review summarizes recent advancements in the biologic characterization of RCC and discusses newly approved therapies and ongoing studies in the treatment of advanced RCC.

Recent findings

The Cancer Genome Atlas has now completed comprehensive molecular characterization of clear cell, papillary, and chromophobe RCC, providing insights into the biology of these entities. Two new 'targeted' therapies, cabozantinib and lenvatinib, as well as a novel immune checkpoi

SUBMITTER: Ball MW 

PROVIDER: S-EPMC5581274 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature